Introduction: Propolis, a resinous substance produced by bees, aroused scientific interest due to its antimicrobial, anti-inflammatory and healing properties. Historically, it was used by various cultures, such as the Egyptians, who used it in embalming. Nowadays, its benefits have been recognized in medicine and dentistry. Its chemical composition rich in flavonoids and phenolic acids made it a valuable natural resource for treating infections and promoting cell regeneration. In dentistry, propolis showed efficacy in areas such as endodontics, periodontics and oral surgery, consolidating itself as a low-cost alternative to conventional treatments.Development: Propolis was identified as an essential substance in beehives to seal cracks and prevent microbial infections. Its antimicrobial activity was attributed to flavonoids, with proven efficacy against Gram-positive bacteria and oral microorganisms associated with caries and periodontitis. In dentistry, it was used for endodontic irrigation, post-surgical healing and as an anticariogenic agent, standing out for its ability to inhibit bacterial growth and accelerate tissue recovery. However, its chemical composition varied according to the local flora, which may influence its consistency. In addition, cases of allergic reactions were identified in people sensitive to bee products.Conclusions: Propolis was consolidated as an effective natural therapeutic resource in medicine and dentistry, standing out for its versatility, low cost and sustainability. However, its clinical integration requires continuous research to standardize its use and minimize allergic risks. This compound represents a promising alternative, aligned with natural approaches in health car
