Introduction: the process of endogenous neurogenesis is not capable of replenishing lost cells after an injury that can result in massive cell loss. Biomaterials are being developed to mimic the brain’s extracellular matrix, providing scaffolds that promote tissue repair and regeneration. The objective was to characterize the application of biomaterials in neurological affections.Methods: a literature review was conducted, where 20 articles in English and Spanish were selected, published in the last five years on the subject, in databases such as: Scopus, PubMed, Springer.Results: biomaterials play an essential role in the human body by serving as artificial substitutes or implants that interact with living tissues, organs, and bodily fluids. Emerging approaches, including stem cell therapy, biomaterials, immune cell therapy, and exosome-based treatments, show promise in modulating the inflammatory response while avoiding broad suppression of immune function. With that in mind, researchers are exploring how these materials could help repair nerve damage once thought to be permanent, boost brain function, and play a key role in fields like neuro-oncology and neuro-rehabilitation. Conclusions: biomaterials enable safe contact with living tissue and offer promise in neuroscience. Research is still needed to address ethics and ensure safe use
