AbstractBackground: Solitary Fibrous Tumors of the Pleura (SFTP) are rare neoplasms deriving from mesenchymal cells. They are mostly benign and may be accompanied by paraneoplastic syndromes, particularly hypoglycaemia and hypertrophic pulmonary osteoarthropathy (HPO).Methods: A case report of a patient with HPO preceding respiratory symptoms secondary to a huge SFTP which was surgically removed and found benign. A literature search was conducted on PubMed using the MeSH terms: secondary hypertrophic osteoarthropathy, solitary fibrous tumor, and solitary fibrous tumor of the pleura. Searches were limited to abstract, full text and English language. Articles from 1946 to 2016 were browsed and relevant articles extracted and reviewed.Results: Our case patient experienced only partial remission of HPO despite benign histology and no signs of recurrence 3 years after surgery. This is in contrast to the literature. This report reviews the various mechanisms suggested to be involved in development of HPO: the humoral, immunologic, and eurogenic theory.Conclusion: SFTP has many factors associated with development of HPO but allthese resolves after surgical resection. Recurrence of HPO is thus indicative of SFTP recurrence, which must be explored thoroughly
