Objective: Aim of our study was to evaluate the prognostic value of pyrogenic cytokines (IL-1β, TNF-α and IL-6)
detection associated with Mid regional pro-Amedullin (MR-proADM) and the APACHE II score in febrile patients
admitted to the Emergency Department (ED).
Material: 64 patients in the Emergency Room (ER) during a period of 12 months with body temperature >37°C
were recruited for this study. In order to compare MR-proADM and cytokine values, a control group of 40 healthy
volunteers was enrolled. For each subject, the APACHE II score was calculated.
Result: MR-proADM and cytokines were significantly higher in patients compared to controls (p<0.0001). When
APACHE II score was correlated to MR-proADM and cytokines and grouped into quartile, it showed a significant
increase in TNF-α and IL-6 levels (p<0.0001). A significant stepwise increase in MR-proADM in accordance with IL-6
quartile levels was observed (p<0.0001). The receiver operating characteristic (ROC) curve showed the abil
