The Editorial Department of Chinese Journal of Clinical Research
Doi
Abstract
Objective To explope the predictive efficacy of serum trimethylamine N ⁃ oxide（TMAO）on myocardial injury after percutaneous coronary intervention（PCI）in patients with coronary heart disease. Methods A total of 200 patients with coronary heart disease who received PCI in Nanchong Central Hospital from June 2020 to June 2023 were selected and divided into myocardial injury group and non⁃myocardial injury group according to whether myocardial injury occurred within 3 months after PCI. The clinical data and serum TMAO levels of the two groups were compared，and the influencing factors of myocardial injury in patients with coronary heart disease after PCI were analyzed by logistic regression. Pearson correlation was used to analyze the correlation between serum TMAO and serum creatine kinase⁃myocardial band（CK⁃MB）and cardiac troponin I（cTnI）. Receiver operating characteristic（ROC）curve was used to analyze the predictive value of serum TMAO on myocardial injury in patients with coronary heart disease after PCI，and R language was used to draw the decision curve. Results During the 3⁃month follow⁃up，7 patients（3.50%）of the 200 patients with coronary heart disease were lost to follow⁃up，4 patients（2.00%）dropped out of the study，and 40 patients（21.16%）of the remaining 189 patients had myocardial injury. There were statistical differences in age，type of coronary heart disease，preoperative statin loading，serum CK⁃MB，serum cTnI and serum TMAO between the myocardial injury group and the non⁃myocardial injury group（P 0.26，and the threshold of high risk was 0- 1.0，which had clinical significance. When the threshold being 0.4- 0.7，serum TMAO could effectively predict myocardial injury in patients with coronary heart disease after PCI. Conclusion Serum TMAO can be used as an effective index to predict myocardial injury in patients with coronary heart disease after PCI. In addition，age，type of coronary heart disease，preoperative loading dose of statin，serum CK⁃MB，serum cTnI，serum TMAO and other factors were associated with myocardial injury in patients with coronary heart disease after PCI
