The Editorial Department of Chinese Journal of Clinical Research
Doi
Abstract
"Objective To investigate the characteristics of liver function，coagulation function，and complications in patients with low viral load hepatitis B virus（HBV）-related cirrhosis.Methods A retrospective study was conducted in 108 patients with low viral load HBV（HBV DNA≤2 000 IU/mL）-related cirrhosis who were treated at Hefei BOE
Hospital from January 2020 to September 2024 as the observation group and 108 patients with HBV DNA >2 000 IU/mL as the control group. The two groups were compared in terms of alanine aminotransferase （ALT），aspartate aminotransferase（AST），alkaline phosphatase（ALP），total bilirubin（TBIL），direct bilirubin（DBIL），indirect bilirubin（IBIL），Child-Turcotte-Pugh（CTP）classification，Model for End-Stage Liver Disease（MELD）score，AST-to-platelet ratio index（APRI），fibrosis-4 index（FIB-4），as well as thrombin time（TT），prothrombin time（PT），activated partial thromboplastin time（APTT），D-dimer（D-D），fibrinogen（Fib），platelet count（PLT），and complications. Results The observation group showed significantly lower levels of ALT，AST，ALP，TBIL，DBIL and IBIL compared to the control group（PPPPPPConclusion Patients with low viral load HBV-related cirrhosis demonstrate better-preserved liver function，milder coagulation dysfunction，and lower incidence of complications，with the main manifestations being splenomegaly，hypersplenism，esophagogastric varices and ascites.
