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Post-transcriptional regulation of amyloid precursor protein by microRNAs and RNA binding proteins
Authors
Amara FM
Broytman O
+30 more
Carlo Cogoni
Ceman S
Cho HH
Christian Barbato
de Sauvage F
Docagne F
Edbauer D
Flanders C
Francesca Ruberti
Goldgaber D
Hardy J
Hentze MW
Hoe HS
Klausner RD
Loffler J
Mbella EG
Moya KL
Napoli I
Nunez-Iglesias J
Patel N
Pluta R
Podlisny MB
Rajagopalan LE
Rogers JT
Rogers JT
Rovelet-Lecrux A
Sabo SL
Theuns J
Vilardo E
Zalfa F
Publication date
1 January 2010
Publisher
'Informa UK Limited'
Doi
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on
PubMed
Abstract
Amyloid Precursor Protein (APP) and its proteolytic product amyloid beta (Aβ) are critical in the pathogenesis of Alzheimer's Disease (AD). APP gene duplication and transcriptional upregulation are linked to AD. In addition, normal levels of APP appear to be required for some physiological functions in the developing brain. Several studies in mammalian cell lines and primary neuron cultures indicate that RNA binding proteins and microRNAs interacting with regulatory regions of the APP mRNA modulate expression of APP post-transcriptionally. However, when the various mechanisms of APP posttranscriptional regulation are recruited and which of them are acting in a synergistic fashion to balance APP protein levels, is unclear. Recent studies suggest that further investigation of the molecules and pathways involved in APP post-transcriptional regulation are warranted. © 2010 Landes Bioscience
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Last time updated on 06/10/2023
Archivio della ricerca- Università di Roma La Sapienza
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Crossref
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info:doi/10.4161%2Fcib.3.6.131...
Last time updated on 05/06/2019