Abstract Background Chronic subdural hematoma (CSDH) typically affects the elderly and is associated with significant morbidity and mortality. However, data on its presentation and outcomes in individuals living with HIV are limited. The purpose of the study was to describe the clinical profile and management outcomes of CSDH in HIV-infected patients. Methods A retrospective review was conducted between January 2006 and December 2022. Patients were stratified into two groups based on CD4 count ≥ and 1.2 and septicemia. Conclusions CSDH in HIV-infected individuals presents at a younger age than in the general population. While most patients had CD4 count of ≥ 200 cells/µL, CD4 level was not a predictor of surgical outcome. Mortality was associated with low GCS, increased INR, and septicemia