Dunachie SJ

Duncan CJ

Klenerman P

Nicols A

Payne RP

Richter A

Turtle L

Wang L

\ua9 Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. The T cell memory response is a crucial component of adaptive immunity responsible for limiting or preventing viral reinfection. T cell memory after infection with the SARS-CoV-2 virus or vaccination is broad, and spans multiple viral proteins and epitopes, about 20 in each individual. So far the T cell memory response is long lasting and provides a high level of cross reactivity and hence resistance to viral escape by variants of the SARS-CoV-2 virus, such as the omicron variant. All current vaccine regimens tested produce robust T cell memory responses, and heterologous regimens will probably enhance protective responses through increased breadth. T cell memory could have a major role in protecting against severe covid-19 disease through rapid viral clearance and early presentation of epitopes, and the presence of cross reactive T cells might enhance this protection. T cell memory is likely to provide ongoing protection against admission to hospital and death, and the development of a pan-coronovirus vaccine might future proof against new pandemic strains

Newcastle University E-Prints

T cell immune memory after covid-19 and vaccination

https://eprints.ncl.ac.uk/file_store/production/307927/B8662C75-49E3-41F1-A2D7-FEDAD280A6A8.pdf

T cell immune memory after covid-19 and vaccination

Abstract

Similar works

Full text

Available Versions

Newcastle University E-Prints