Secondary acute lymphoblastic leukemia (sALL) following
acute myeloid leukemia (AML) is a rare event;
only eight cases have been reported. We report a
patient with acute promyelocytic leukemia (APL), in
hematological and molecular remission who developed
T-ALL three years after the diagnosis of APL.
The morphological, cytochemical, phenotypical and
molecular features of this T-ALL were different from
those of the previous APL. The absence of t(15;17),
negative PML/RAR. at reverse transcription polymerase
chain reaction (RT-PCR) analysis and presence
of TcR. support the hypothesis that the T-ALL
in this sALL case originated from a different clone
from that of the APL cells
