Baumlova, A.

Birkus, G.

Boura, E.

Chalupska, D.

Dejmek, M.

Guillon, R.

Hrebabecky, H.

Kögler, M.

Lee, G.

Mejdrova, I.

Mertlikova Kaiserova, H.

Nencka, R.

Plackova, P.

Prochazkova, E.

Sala, M.

Strunin, D.

Weber, J.

Phosphatidylinositol 4 kinase III amp; 946; is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to modify the structure of intracellular membranes and use them for the construction of functional replication machinery. Selective inhibitors of this enzyme are potential broad spectrum antiviral agents, as inhibition of this enzyme results in the arrest of replication of PI4K III amp; 946; dependent viruses. Herein, we report a detailed study of novel selective inhibitors of PI4K III amp; 946;, which exert antiviral activity against a panel of single stranded positive sense RNA viruses. Our crystallographic data show that the inhibitors occupy the binding site for the adenine ring of the ATP molecule and therefore prevent the phosphorylation reactio

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Highly Selective Phosphatidylinositol 4 Kinase III beta Inhibitors and Structural Insight into Their Mode of Action

Highly Selective Phosphatidylinositol 4 Kinase III beta Inhibitors and Structural Insight into Their Mode of Action

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