International audienceWe study the Dirichlet problem for the non-local diffusion equation u_t=\int\{u(x+z,t)-u(x,t)\}\dmu(z), where μ is a L1 function and ‘‘u=φ on ∂Ω×(0,∞)'' has to be understood in a non-classical sense. We prove existence and uniqueness results of solutions in this setting. Moreover, we prove that our solutions coincide with those obtained through the standard ``vanishing viscosity method'', but show that a boundary layer occurs: the solution does not take the boundary data in the classical sense on ∂Ω, a phenomenon related to the non-local character of the equation. Finally, we show that in a bounded domain, some regularization may occur, contrary to what happens in the whole space