The role of progestogens in Hormone Replacement
Therapy (HRT) is to counteract the estrogen-
dependent endometrial mitotic stimulation,
thus significantly reducing hyperplasia/carcinoma
risk of endometrial cells. Progestogens are different
for pharmacological potency, secondary effects
on other receptors than progestin receptor,
and metabolic effect on various tissues (e.g.,
breast) and systems (e.g., cardiovascular, central
nervous system) of the women’s body. This review
summarizes current data on progestogen’s
pharmacological role in HRT use for menopause
managemen
