Changes in sulphatide concentrations in the oviduct of the frog Rana escultenta induced by estradiol administration in ovariectomized and hypophysiectomized animals have been studied by means of biochemical methods. Variations in sulphatide concentration were attributed to indirect action of estradiol that by induction of arylsulphatase activity affected the catabolic phase of the sulpholipid matabolism. The remarkable increase in sulphatides observed in hypophysiectomized animals led us to also propose an indirect control by the pituitary gland
