Kisten ras mutations in patients with colorectal cancer: the “RASCAL II” study.

AL MULLA F; ANDERSEN SN; ANDREYEV HJN; ARENDS JW; BAZAN V; BELL S; BENAMOUZIG R; BENHATTAR J; BERANEK M; BREIVIK J; BUBB VJ; CLARKE PA; CLAUSEN OPF; COSTA J; CROKE CT; CRUICKSHANK NR; CUNNINGHAM D; DE ANGELIS P; DE GOEIJ AFPM; DILLON D; DIX BR; FABER C; FILKENSTEIN SD; FONT A; FOX JC; FUJIMORI T; GAUDERNACK G; GIARETTI W; GLAESENER R; GOH H. S; HALL CN; HALTER SA; HAWKINS N; HO JWC; HOFFMANN I; IACOPETTA BJ; JANDIK P; JULLIAN E; KRTOLICA K; LAURENT PUIG P; LEE JQ; LEES N; LOSI, Lorena; LOVIG T; MALIK S; MELING GI; MORTON D; MULLER O; NORMAN AR; OATES J; ODONOGUE DP; OLSCHWANG S; OMURA K; ONKUSA T; ONO Y; PAULY M; PIRIS J; PRICOLO VE; QUIRKE P; RABES HM; RAPALLO A; ROGNUM TO; ROSELL R; RUSSO A; SENAGORE AJ; SMITH R; SNARY D; SUN XF; TANAKA M; THEBO JS; TROUNGOS C; UROSEVIC N.; VALAVANIS C; WADLER S; WALSH T; WANG ST; WARD R; WILKINSON K; YOUNG J; YUEN ST; ZHANG H; ZIETZ C

Kisten ras mutations in patients with colorectal cancer: the “RASCAL II” study.

Authors: AL MULLA F
ANDERSEN SN
ANDREYEV HJN
ARENDS JW
BAZAN V
BELL S
BENAMOUZIG R
BENHATTAR J
BERANEK M
BREIVIK J
BUBB VJ
CLARKE PA
CLAUSEN OPF
COSTA J
CROKE CT
CRUICKSHANK NR
CUNNINGHAM D
DE ANGELIS P
DE GOEIJ AFPM
DILLON D
DIX BR
FABER C
FILKENSTEIN SD
FONT A
FOX JC
FUJIMORI T
GAUDERNACK G
GIARETTI W
GLAESENER R
GOH H. S
HALL CN
HALTER SA
HAWKINS N
HO JWC
HOFFMANN I
IACOPETTA BJ
JANDIK P
JULLIAN E
KRTOLICA K
LAURENT PUIG P
LEE JQ
LEES N
Lorena LOSI
LOVIG T
MALIK S
MELING GI
MORTON D
MULLER O
NORMAN AR
OATES J
ODONOGUE DP
OLSCHWANG S
OMURA K
ONKUSA T
ONO Y
PAULY M
PIRIS J
PRICOLO VE
QUIRKE P
RABES HM
RAPALLO A
ROGNUM TO
ROSELL R
RUSSO A
SENAGORE AJ
SMITH R
SNARY D
SUN XF
TANAKA M
THEBO JS
TROUNGOS C
UROSEVIC N.
VALAVANIS C
WADLER S
WALSH T
WANG ST
WARD R
WILKINSON K
YOUNG J
YUEN ST
ZHANG H
ZIETZ C
Publication date: 1 January 2001
Publisher: Editore attuale:NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON, ENGLAND, N1 9XW Harcourt Publishers Limited:Foots Cray High Street, Sidcup Kent DA14 5HP United Kingdom:011 44 20 83085700, EMAIL: [email protected], INTERNET: http://www.harcourt-international.com, Fax: 011 44 20 83085876

Abstract

This collaborative study suggests that not only is the presence of a codon 12 glycine to valine mutation important for cancer progression but also that it predispose to more aggressive biological behaviour in patients with advanced colorectal cancer

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