First-generation college students (FGCS) face a unique set of challenges that can hinder their academic, financial, and social success in higher education. These challenges often stem from a lack of familial academic experience, limited financial resources, and unfamiliarity with institutional systems. This paper explores the multifaceted barriers encountered by FGCS, including academic preparedness gaps, financial stressors, social isolation, and conflicting family expectations. Drawing from research and personal experience, it also proposes practical, evidence-based solutions that student affairs professionals can implement to improve outcomes for FGCS. These include bridge programs, peer mentorship, financial literacy initiatives, culturally responsive support services, and family engagement strategies. The paper advocates for a holistic and inclusive approach to student support that empowers FGCS to thrive academically and personally throughout their college journey