Gay, S

Guglielmotti, V

Lavecchia, T

Orlanducci, S

Reina, G

Rossi, M

Tamburri, E

Terranova, ML

ORLANDUCCI, SILVIA

REINA, GIACOMO

TAMBURRI, EMANUELA

TERRANOVA PERSICHELLI, MARIA LETIZIA

Rossi, M.

English

Engineered nanocarbon surfaces for nanomedicine

Archivio della Ricerca - Università di Roma Tor vergata

European Cells and Materials Vol. 26. Suppl. 6, 2013 (page 96)                                                            ISSN 1473-2262 
 
                                                http://www.ecmjournal.org 
 
Engineered nanocarbon surfaces for nanomedicine  
S Orlanducci1, S Gay1, G Reina1,2, V Guglielmotti1,2, E Tamburri1, T Lavecchia1, ML Terranova1, 
M Rossi3 
1 Minimalab, Dip. di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Via della 
Ricerca Scientifica 00133 Roma, Italy. 2 Nanoshare s.r.l.Via G. Peroni 386, 00131 Roma, Italy 
3 Electron Microscopies and Nanoscopies (EMiNa) Lab, Department of Basic and Applied Sciences 
for Engineering, and Sapienza Nanotechnologies and Nanosciences (SNN) Lab, CNIS, University of 
Rome Sapienza, Rome Italy 
 
INTRODUCTION: The research of new 
materials and multimodal architectures for 
nanomedicine is today a rapidly developing 
research area and functional systems engineered at 
the nanoscale are finding wide application for 
prevention, diagnosis and treatment of diseases. 
These systems provide promising alternatives to 
conventional biosensors, and open completely new 
routes to imaging/labeling, to drug delivery, to 
fabrication of micro- and nano-scale scaffolds for 
tissue growth. 
However, for biomedical applications, composition 
and structure of the surfaces contacting biological 
systems must meet strict requirements in terms of 
biocompatibility and long-time reliability. 
Recent researches demonstrated that, among the 
inorganic materials used in nanomedicine, the sp2    
and the sp3 hybridized nanocarbons have the 
primacy. 
It has been proven that nanodiamond is excellent 
substrate for the adhesion and growth of several 
types of cells in vitro, and that its surface can 
selectively bind various biological molecules. In 
this context, nanodiamond can be considered a 
good candidate for bio-implants, for controlled 
administration of therapeutic agents, as well as an 
ideal surface for site-specific targeting/labeling and 
for sensing/detecting biological systems1,2 . 
As regards sp2 carbon, fullerenes, graphite 
nanoplatelets, carbon nanofibers and nanotubes 
have been tested as drug delivery platforms, as 
sensing elements and reinforcing agents for bio-
devices, as tools for separating and purifying 
biological systems. 
RESULTS: In our labs a variety of different 
strategies are being explored to prepare specifically 
shaped surfaces enabling nanocarbon-based 
bioapplications. In particular, graphitic dendrimers 
with various size, shape, branching and surface 
functionality and nanodiamond systems formed by 
elongated structures (nanorods, nanowhiskers, 
nanopillars nanocones) are proposed as attractive 
scaffolds for tissue growth, for selective 
attachment of targeting groups and for 
bioanalytical applications. 
This presentation will illustrate some relevant 
synthetic strategies for the engineering of 
nanocarbon-based platforms and some examples of 
multivalent architectures for bio-related 
applications. 
 
 
Fig. 1: Examples of dendridic carbon structures. 
 
REFERENCES: 1Xiao X, Wang J, Liu C, Carlisle 
JA, Mech B, Greenberg R, Guven D, Freda R, 
Humayun MS, Weiland J, Auciello O (2006) J 
Biomed Mater Res B Appl Biomater. 77(2): 273-
81. 2Yang W, Auciello O, Butler JE, Cai W, 
Carlisle JA, Gerbi JE, Gruen DM, Knickerbocker 
T, Lasseter TL, Russell JN Jr, Smith LM, Hamers 
RJ. (2002) Nature Material 1(4): 253-7. 3 S. 
Orlanducci, V. Guglielmotti, V. Sessa, E. 
Tamburri, M.L. Terranova, F. Toschi, M. Rossi, 
(2012) Mater. Res. Soc. Symp. Proc. 1395, 93-98. 


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Engineered nanocarbon surfaces for nanomedicine

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