The purpose of this study was to describe the efficacy of
planned combined subintimal arterial flossing with antegrade–
retrograde intervention (SAFARI) to obtain the precise
recanalization of the patent portion of a distal runoff
vessel in critical limb ischemia (CLI) patients presenting
long occlusions involving the popliteal trifurcation. Four
patients at risk of limb loss due to long occlusions involving
the leg vessel tree and not suitable for a surgical bypass
were treated by the subintimal antegrade and retrograde
(posterior tibial or anterior tibial artery) approach. The
patent portion of the runoff vessel was previously assessed
by magnetic resonance angiography (MRA) and directly
punctured under Doppler ultrasound (US) guidance. A
subintimal channel rendezvous was performed to allow
snaring of the guidewires. Subsequently, a balloon dilatation
was performed without stent deployment. All patients were
successfully recanalized and had complete healing of the
limb lesions. At the 12-month follow-up all patients showed
clinical improvement with no major complications related to
the procedure. This combined antegrade and retrograde
subintimal approach is currently an excellent endovascular
option in patients with long occlusions extending onto the
leg vessels trifurcation and at risk of limb loss.
Key words: Critical limb ischemia—Subintimal technique—
Popliteal branches—Retrograde acces