CAPORALE, ANGELAMARIA

De Martino, F.

De Prisco, R

Essolito, M

Marra, N

Nicolaus, B

POPOLO, Ada

Saturnino, C

Tommonaro, G

English

Archivio della Ricerca - Università di Salerno

Translational Medicine @ UniSa - ISSN 2239-9747 2014, Special Issue (1): 11  Giornate della Facoltà di Farmacia e Medicina a Salerno Campus di Fisciano dell'Università di Salerno presso il Dipartimento di Farmacia  22 e 23 maggio 2014   11 Università degli Studi di Salerno Definition of Cytotoxic, Antioxidant and Heavy Metals Activity of Tomatoes Grown in Toxic Muddy Soils.  Marra N1*, Caporale A1, Tommonaro G2, Popolo A1, De Prisco R2, Nicolaus B2, Saturnino C1, Essolito M1, De Martino F3.  1 Department of Pharmacy, University of Salerno, Via Giovanni Paolo II  132, 84084, Fisciano (SA), Italy. 2 National Research Board- Biomolecolar Chemistry Institute , Via Campi Flegrei 34, 80078, Pozzuoli (NA). 3Department of Chemistry and Biology, Via Giovanni Paolo II  132, 84084, Fisciano (SA), Italy.  Fruits of Solanum Lycopersicum, well-known as tomatoes, have got an high contents of essential nutritive elements for human health. They are rich of a several vitamins (C, A, B group, D, K) and minerals (P, Fe, Ca, Mg, Mn, Cu, K, Na) besides to be very rich in flavonoids and lycopene. These characteristics make tomatoes the best allies against cancer disease and an essential food for a good feeding. Our investigation is focused on tomatoes grown in polluted soils to check their phytochemical and nutritive features.  With this aim, we have drawn skim, juice and seeds from tomatoes grown in muddy soils and have verified the antioxidant power and the anticancer activity of bioactive metabolities being in them, further the presence of possible heavy metals.  We have performed antioxidant assay on ethanol drawns using DDPH; while ethereal drawns antioxidant activity has been evaluated according to ABTS assay. The results of antioxidant assay show tomatoes keep an high antioxidant activity, mostly in their lypophile fraction, rich of the most representative compounds.  Citotoxicity assay have been performed on HeLa, PDAC, A375, cells line and the results, both for chloroformic and ethanol drawns, for the seeds and for tomato juice are negative, because of they don’t show a clear citotoxicity.  As regards heavy metal presence, has been evaluated using spectroscopy of atomic absorption with graphite oven, and the performed tests show the absence of heavy metals. These results have a great scientific role, because they open a promising pathway to follow for the primary prevention of a several widespread disease.   

Definition of Cytotoxic, Antioxidant and Heavy Metals Activity of Tomatoes Grown in Toxic Muddy Soils

https://www.iris.unisa.it/bitstream/11386/4368255/1/Definition_giornate%20di%20Medicina%202014.pdf

Definition of Cytotoxic, Antioxidant and Heavy Metals Activity of Tomatoes Grown in Toxic Muddy Soils

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Archivio della Ricerca - Università di Salerno