3Interstitial granulomatous dermatitis (IGD) is a rare dermatosis of unknown cause with characteristic histopathological features and variable clinical expression. [1] It has been associated with systemic diseases which include rheumatoid arthritis, lupus erythematosus, autoimmune thyroiditis, carcinoma, infections and drug intake. It has recently been proposed that interstitial granulomatous dermatitis could be a cutaneous manifestation of Lyme borreliosis in Borrelia burgdorferi endemic areas. [2],[3],[4] We report a similar case below.openopenDI MEO, N.; Stinco, G.; Trevisan, G.DI MEO, Nicola; Stinco, G.; Trevisan, Giust

Di Meo, Nicola

Stinco, Giuseppe

Trevisan, Giusto

Indian Journal of Dermatology, Venereology and Leprology

STINCO, Giuseppe

Archivio istituzionale della ricerca - Università degli Studi di Udine

Indian Journal ofDermatology, Venereology & LeprologyAn IADVL PublicationMay-June2015Issue 3 Volume 81www.ijdvl.comIndian Journal of Dermatology, Venereology & Leprology     •     Volume 81     •     Issue 3     •     May - June 2015     •     Pages 237-00**In the Issue… Missing issues Nocebo effect in Dermatology Weekly azathioprine pulse versus daily azathioprine in the treatment of Parthenium dermatitis: A non-inferiority randomized controlled study Evaluation of the effect of Block Level Awareness Campaign on performance indicators of National Leprosy Elimination Program in Vadodara district, Gujarat, IndiaSir,Interstitial granulomatous dermatitis (IGD) is a rare dermatosis of unknown cause with characteristic histopathological features and variable clinical expression.[1] It has been associated with systemic diseases which include rheumatoid arthritis, lupus erythematosus, autoimmune thyroiditis, carcinoma, infections and drug intake. It has recently been proposed that interstitial granulomatous dermatitis could be a cutaneous manifestation of Lyme borreliosis in Borrelia burgdorferi endemic areas.[2-4] We report a similar case below.A 63-year-old farmer presented with asymptomatic, asymmetric, erythematous plaques with elevated borders and an annular rope like configuration over his back. The lesions had been progressively enlarging over the last 8 months [Figure 1]. He also suffered from malaise, non specific myalgia and arthritis since the onset. A punch biopsy specimen taken from a skin lesion showed a normal epidermis and a perivascular and interstitial diffuse infiltrate in the dermis comprising of lymphocytes, histiocytes and a few giant cells without any mucin deposits[Figure 2]. Palisading granulomas consisting of histiocytes surrounding focally degenerated eosinophilic collagen were also present. The ‘floating sign’ was recognizable, which is characterized by histiocytic pseudorosettes that surround an empty space centered by degenerated collagen fibers [Figure 3]. A diagnosis of interstitial granulomatous dermatitis was made.There was no history of drug intake, autoimmune disorders or malignancy. Five months prior to the onset of these lesions, he had developed an erythematous patch over his left thigh one week after a tick bite over the same area. This resulted in a ‘bull’s-eye’ appearance which gradually expanded over a period of several days and measured 15 cm across. It spontaneously resolved without any treatment one month later. We performed a two-tiered antibody testing for Lyme disease. High titres of IgG and IgM were detected with the ELISA rapid test (IgG: 233 UA/ml, IgM: 178 UA/ml; normal values:<24 UA/ml) and confirmed by the western blot test. Real time quantitative polymerase chain reaction assays were positive to Borrelia burgdorferi. The patient was treated with doxycycline 200 mg daily for 21 days and hydroxychloroquine 400 mg daily for 4 months with complete resolution of skin lesions and arthromyalgia.The clinical presentation of interstitial granulomatous dermatitis is quite heterogeneous. Annular patches and non-tender multiple erythematous papules, nodules or plaques on the trunk and proximal Figure 1: Annular dermatitis depicting the ‘Rope sign’Figure 2: Interstitial diffuse infi ltrate of the dermis comprising of lymphocytes, histiocytes and a few giant cells without mucin depositionNet Letter Interstitial granulomatous dermatitis due to borreliosisHow to cite this article: di Meo N, Stinco G, Trevisan G. Interstitial granulomatous dermatitis due to borreliosis. Indian J Dermatol Venereol Leprol 2015;81:327.Received: January, 2014. Accepted: May, 2014. Source of Support: Nil. Confl ict of Interest: None declared.Net Letterextremities are the usual features. Differential diagnoses include all the other conditions that present with erythematous plaques. The presence of cord-like skin lesions (rope sign) is characteristic but is only present in a few patients.[1] Skin lesions are usually asymptomatic or mildly symptomatic. Histopathology reveals an interstitial and palisading granulomatous dermatitis accompanied by piecemeal fragmentation of collagen and elastic fibres. This process is usually accentuated in the reticular dermis but abnormalities can also involve the full thickness of the dermis or hypodermis. The ‘floating sign’ has been reported in most published cases. Rare giant multinucleated histiocytes or atypical histiocytes, perivascular and interstitial lymphocytic infiltrates are present in most of the cases described. Epidermal changes, presence of mucin deposits and leukocytoclastic vasculitis are typically absent.[1] Histologically, the main differential diagnoses include interstitial granuloma annulare, palisaded neutrophilic granulomatous dermatitis, granulomatous reactions to drugs, histiocytoid Sweet syndrome and Churg Strauss granulomatosis.Interstitial granulomatous dermatitis has been reported in association with autoimmune diseases, lymphoproliferative disorders, solid organ cancers and several systemic drugs. In the last decade, Borrelia burgdorferi has been identified in some cases.[2-4] These usually appeared in the intermediate stage of Lyme disease (between erythema migrans and acrodermatitis chronica atrophicans). It is important to note that the clinical features of the reported cases were similar to those of morphea, erythema migrans and granuloma annulare.[2-4] In our case, the lesions had features more typical for interstitial granulomatous dermatitis. The mechanism of this association is unknown but it can be assumed that Borrelia antigens persist in different skin sites, stimulating a granulomatous reaction.In conclusion, interstitial granulomatous dermatitis due to Borrelia burgdorferi infection is certainly a rare clinical manifestation. Recognizing this entity is only achieved through a combined of clinical, histological and molecular approach. It is important to consider this association, especially in endemic areas, in order to provide adequate treatment.Nicola  di Meo, Giuseppe Stinco1, Giusto TrevisanInstitute of Dermatology and Venereolgy, Department of Medical Science, University of Trieste, Trieste, 1Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, Udine, Italy Address for correspondence: Dr. Nicola di Meo, Institute of Dermatology and Venereology, University of Trieste, Italy Ospedale Maggiore di Trieste, IV Piano Palazzina Infettivi, Piazza Ospedale 1, 34100 Trieste, Italy. E-mail: nickdimeo@libero.itREFERENCES1. Peroni A, Colato C, Schena D, Gisondi P, Girolomoni G. Interstitial granulomatous dermatitis: A distinct entity with characteristic histological and clinical pattern. Br J Dermatol 2012;166:775-83.2. Moreno C, Kutzner H, Palmedo G, Goerttler E, Carrasco L, Requena L. Interstitial granulomatous dermatitis with histiocytic pseudorosettes: A new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. J Am Acad Dermatol 2003;48:376-84.3. Gualco F, Zaccaria E, Drago F, Rebora A. Interstitial granuloma annulare and borreliosis: A new case. J Eur Acad Dermatol Venereol 2007;21:1117-8.4. Fernandez-Flores A, Ruzic-Sabljic E. Granuloma annulare displaying pseudorosettes in Borelia infection. Acta Dermatovenerol Alp Panonica Adriat 2008;17:171-6.Figure 3: The ‘floating sign’. Histiocytic pseudorosettes surrounding an empty space centered by degenerated collagen fi bersAccess this article onlineQuick Response Code: Website: www.ijdvl.comDOI: 10.4103/0378-6323.154783PMID:*****

Interstitial granulomatous dermatitis due to borreliosis

Interstitial granulomatous dermatitis (IGD) is a rare dermatosis of unknown cause with characteristic histopathological features and variable clinical expression. [1] It has been associated with systemic diseases which include rheumatoid arthritis, lupus erythematosus, autoimmune thyroiditis, carcinoma, infections and drug intake. It has recently been proposed that interstitial granulomatous dermatitis could be a cutaneous manifestation of Lyme borreliosis in Borrelia burgdorferi endemic areas. [2],[3],[4] We report a similar case below

DI MEO, NICOLA

TREVISAN, GIUSTO

Stinco, G.

Archivio istituzionale della ricerca - Università di Trieste

Sir,Interstitial granulomatous dermatitis (IGD) is a rare dermatosis of unknown cause with characteristic histopathological features and variable clinical expression.[1] It has been associated with systemic diseases which include rheumatoid arthritis, lupus erythematosus, autoimmune thyroiditis, carcinoma, infections and drug intake. It has recently been proposed that interstitial granulomatous dermatitis could be a cutaneous manifestation of Lyme borreliosis in Borrelia burgdorferi endemic areas.[2-4] We report a similar case below.A 63-year-old farmer presented with asymptomatic, asymmetric, erythematous plaques with elevated borders and an annular rope like configuration over his back. The lesions had been progressively enlarging over the last 8 months [Figure 1]. He also suffered from malaise, non specific myalgia and arthritis since the onset. A punch biopsy specimen taken from a skin lesion showed a normal epidermis and a perivascular and interstitial diffuse infiltrate in the dermis comprising of lymphocytes, histiocytes and a few giant cells without any mucin deposits[Figure 2]. Palisading granulomas consisting of histiocytes surrounding focally degenerated eosinophilic collagen were also present. The ‘floating sign’ was recognizable, which is characterized by histiocytic pseudorosettes that surround an empty space centered by degenerated collagen fibers [Figure 3]. A diagnosis of interstitial granulomatous dermatitis was made.There was no history of drug intake, autoimmune disorders or malignancy. Five months prior to the onset of these lesions, he had developed an erythematous patch over his left thigh one week after a tick bite over the same area. This resulted in a ‘bull’s-eye’ appearance which gradually expanded over a period of several days and measured 15 cm across. It spontaneously resolved without any treatment one month later. We performed a two-tiered antibody testing for Lyme disease. High titres of IgG and IgM were detected with the ELISA rapid test (IgG: 233 UA/ml, IgM: 178 UA/ml; normal values:<24 UA/ml) and confirmed by the western blot test. Real time quantitative polymerase chain reaction assays were positive to Borrelia burgdorferi. The patient was treated with doxycycline 200 mg daily for 21 days and hydroxychloroquine 400 mg daily for 4 months with complete resolution of skin lesions and arthromyalgia.The clinical presentation of interstitial granulomatous dermatitis is quite heterogeneous. Annular patches and non-tender multiple erythematous papules, nodules or plaques on the trunk and proximal Figure 1: Annular dermatitis depicting the ‘Rope sign’Figure 2: Interstitial diffuse infi ltrate of the dermis comprising of lymphocytes, histiocytes and a few giant cells without mucin depositionNet Letter Interstitial granulomatous dermatitis due to borreliosisHow to cite this article: di Meo N, Stinco G, Trevisan G. Interstitial granulomatous dermatitis due to borreliosis. Indian J Dermatol Venereol Leprol 2015;81:327.Received: January, 2014. Accepted: May, 2014. Source of Support: Nil. Confl ict of Interest: None declared.Net Letterextremities are the usual features. Differential diagnoses include all the other conditions that present with erythematous plaques. The presence of cord-like skin lesions (rope sign) is characteristic but is only present in a few patients.[1] Skin lesions are usually asymptomatic or mildly symptomatic. Histopathology reveals an interstitial and palisading granulomatous dermatitis accompanied by piecemeal fragmentation of collagen and elastic fibres. This process is usually accentuated in the reticular dermis but abnormalities can also involve the full thickness of the dermis or hypodermis. The ‘floating sign’ has been reported in most published cases. Rare giant multinucleated histiocytes or atypical histiocytes, perivascular and interstitial lymphocytic infiltrates are present in most of the cases described. Epidermal changes, presence of mucin deposits and leukocytoclastic vasculitis are typically absent.[1] Histologically, the main differential diagnoses include interstitial granuloma annulare, palisaded neutrophilic granulomatous dermatitis, granulomatous reactions to drugs, histiocytoid Sweet syndrome and Churg Strauss granulomatosis.Interstitial granulomatous dermatitis has been reported in association with autoimmune diseases, lymphoproliferative disorders, solid organ cancers and several systemic drugs. In the last decade, Borrelia burgdorferi has been identified in some cases.[2-4] These usually appeared in the intermediate stage of Lyme disease (between erythema migrans and acrodermatitis chronica atrophicans). It is important to note that the clinical features of the reported cases were similar to those of morphea, erythema migrans and granuloma annulare.[2-4] In our case, the lesions had features more typical for interstitial granulomatous dermatitis. The mechanism of this association is unknown but it can be assumed that Borrelia antigens persist in different skin sites, stimulating a granulomatous reaction.In conclusion, interstitial granulomatous dermatitis due to Borrelia burgdorferi infection is certainly a rare clinical manifestation. Recognizing this entity is only achieved through a combined of clinical, histological and molecular approach. It is important to consider this association, especially in endemic areas, in order to provide adequate treatment.Nicola  di Meo, Giuseppe Stinco1, Giusto TrevisanInstitute of Dermatology and Venereolgy, Department of Medical Science, University of Trieste, Trieste, 1Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, Udine, Italy Address for correspondence: Dr. Nicola di Meo, Institute of Dermatology and Venereology, University of Trieste, Italy Ospedale Maggiore di Trieste, IV Piano Palazzina Infettivi, Piazza Ospedale 1, 34100 Trieste, Italy. E-mail: nickdimeo@libero.itREFERENCES1. Peroni A, Colato C, Schena D, Gisondi P, Girolomoni G. Interstitial granulomatous dermatitis: A distinct entity with characteristic histological and clinical pattern. Br J Dermatol 2012;166:775-83.2. Moreno C, Kutzner H, Palmedo G, Goerttler E, Carrasco L, Requena L. Interstitial granulomatous dermatitis with histiocytic pseudorosettes: A new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. J Am Acad Dermatol 2003;48:376-84.3. Gualco F, Zaccaria E, Drago F, Rebora A. Interstitial granuloma annulare and borreliosis: A new case. J Eur Acad Dermatol Venereol 2007;21:1117-8.4. Fernandez-Flores A, Ruzic-Sabljic E. Granuloma annulare displaying pseudorosettes in Borelia infection. Acta Dermatovenerol Alp Panonica Adriat 2008;17:171-6.Figure 3: The ‘floating sign’. Histiocytic pseudorosettes surrounding an empty space centered by degenerated collagen fi bersAccess this article onlineQuick Response Code: Website: www.ijdvl.comDOI: 10.4103/0378-6323.154783PMID:*****Copyright of Indian Journal of Dermatology, Venereology & Leprology is the property ofMedknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed tomultiple sites or posted to a listserv without the copyright holder's express written permission.However, users may print, download, or email articles for individual use.

Interstitial granulomatous dermatitis due to borreliosis

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