Beach D

Draetta G

Franza BR Jr

Giordano A

Harlow E

Whyte P

p60 is a cellular protein that binds to the adenovirus E1A protein complex in virally infected or transformed human cells. In both infected and uninfected cells, p60 was found in a complex with the cdc2 protein kinase. Immune complexes containing p60 and cdc2 display a cell cycle-dependent histone H1 kinase activity that is most active in interphase. The previously described cdc2-p62/cyclin complex also acts as a histone H1 kinase but is maximally active in mitotic metaphase. The shift in the timing of activation of different cdc2-containing complexes suggests that each might play a distinct role in regulation of the cell cycle. © 1989

Giordano, A.

Whyte, P.

Harlow, E.

Franza, B. R. Jr

Beach, D.

Draetta, G.

Archivio della Ricerca - Università degli Studi di Siena

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells.

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Archivio della Ricerca - Università degli Studi di Siena