ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)
The American College of Medical Genetics and Genomics (ACMG) previously published guidance for reporting secondary findings in the context of clinical exome and genome sequencing (ES/GS) in 2013 and 2017. These recommendations were developed by the ACMG Secondary Findings Maintenance Working Group (SFWG), which was convened by the ACMG Board of Directors (BOD) to evaluate the need for a minimum list of genes that should be evaluated in individuals undergoing clinical ES/GS based on the medical actionability of the associated condition. In the past, policy recommendations concerning what types of variants to return along with lists of which genes to analyze were included. Given the increase in uptake of clinical ES/GS, the ACMG SFWG and BOD have agreed the list of recommended genes should now be updated annually. Policy updates surrounding the purpose, scope, and process for maintaining the ACMG Secondary Findings List are being published separately, and will be updated separately, as needed. It is important to reiterate here that use of the SF results should not be a replacement for indication-based diagnostic clinical genetic testing
