Bonaldo, Paolo

Cescon, Matilde

Chen, Peiwen

Autophagy

Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression. © 2014 Landes Bioscience

CHEN, PEIWEN

CESCON, MATILDE

BONALDO, PAOLO

Archivio istituzionale della ricerca - Università di Padova

Autophagy-mediated regulation of macrophages and its applications for cancer.

Peiwen Chen

Matilde Cescon

Paolo Bonaldo

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Autophagy-mediated regulation of macrophages and its applications for cancer

Autophagy-mediated regulation of macrophages and its applications for cancer.

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Archivio istituzionale della ricerca - Università di Padova

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