Bampasakis, Dimitris

Davey, N.

Maex, Reinoud

Steuber, Volker

University of Hertfordshire Research Archive

POSTER PRESENTATION Open AccessShort-term depression of inhibitory Purkinje cellsynapses enhances gain modulation in thecerebellar nucleiDimitris Bampasakis1*, Reinoud Maex2, Neil Davey1, Volker Steuber1From Twenty Second Annual Computational Neuroscience Meeting: CNS*2013Paris, France. 13-18 July 2013Information in neurons can be encoded by their actionpotential rate, thus making the transformation of input tooutput rate, the input-output (I-O) relationship, a corecomputational function. Introduction of a second input,often called modulatory input, can modify this I-Orelationship in ways that correspond to differentarithmetic operations [1]. Here, we examine the modula-tion of the slope of the I-O relationship, also referred to asgain modulation.Gain modulation can be based on a wide variety ofbiophysical mechanisms, with short-term depression(STD) of excitatory synapses being one of them [2].* Correspondence: d.bampasakis@herts.ac.uk1Science and Technology Research Institute, University of Hertfordshire,Hatfield AL10 9AB, UKFigure 1 Gain change due to excitatory modulatory input. Left: Average output rate of the CN neuron as a function of PC inhibitory input,for 20 Hz and 50 Hz excitatory mossy fibre input. Dots and lines correspond to simulation data and fits of a Hill function, respectively. Right:Change in gain and offset (calculated as in [2]) in the presence and absence of STD for 20 Hz of excitatory rate (left bars), and for a change ofthe excitation from 20 Hz to 50 Hz in the absence (middle bars) and presence (right bars) of STD.Bampasakis et al. BMC Neuroscience 2013, 14(Suppl 1):P374http://www.biomedcentral.com/1471-2202/14/S1/P374© 2013 Bampasakis et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the CreativeCommons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, andreproduction in any medium, provided the original work is properly cited.Commonly, gain modulation is studied by examining theeffect of tonic or synaptic inhibition on the excitatory I-Orelationship. However, some projection neurons, like cere-bellar Purkinje cells (PCs), are inhibitory. Therefore, theopposite scenario, in which the effect of inhibition on out-put rate is being modulated by an excitatory input, mayoccur as well. As a previous study found that inhibitorysynaptic input variability can change the output rate ofneurons in the cerebellar nuclei (CN) [3], the questionarises how excitatory input can modulate this relationship.Considering the excitatory input from mossy fibres (MF)onto CN neurons as modulatory, we investigated theeffects on gain control exerted by STD of the inhibitorysynapses that PCs make on a model CN neuron [3]. Wefound that STD at the inhibitory PC-CN synapseenhanced gain modulation (Figure 1). Thus, like STD atexcitatory synapses, STD at inhibitory synapses can enableneurons to perform multiplicative operations on theirinputs.Author details1Science and Technology Research Institute, University of Hertfordshire,Hatfield AL10 9AB, UK. 2Department of Cognitive Sciences, École NormaleSupérieure, Paris 75005, France.Published: 8 July 2013References1. Silver RA: Neuronal arithmetic. Nature Reviews Neuroscience 2010,11:474-489.2. Rothman JS, Cathala L, Steuber V, Silver RA: Synaptic depression enablesneuronal gain control. Nature 2009, 457:1015-1018.3. Luthman J, Hoebeek FE, Maex R, Davey N, Adams R, De Zeeuw CI,Steuber V: STD-dependent and independent encoding of inputirregularity as spike rate in a computational model of a cerebellarnucleus neuron. Cerebellum 2011, 10:667-682.doi:10.1186/1471-2202-14-S1-P374Cite this article as: Bampasakis et al.: Short-term depression of inhibitoryPurkinje cell synapses enhances gain modulation in the cerebellarnuclei. BMC Neuroscience 2013 14(Suppl 1):P374.Submit your next manuscript to BioMed Centraland take full advantage of: • Convenient online submission• Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistributionSubmit your manuscript at www.biomedcentral.com/submitBampasakis et al. BMC Neuroscience 2013, 14(Suppl 1):P374http://www.biomedcentral.com/1471-2202/14/S1/P374Page 2 of 2

Short-term depression of inhibitory Purkinje cell synapses enhances gain modulation in the cerebellar nuclei

https://uhra.herts.ac.uk/id/eprint/4346/1/906758.pdf

Short-term depression of inhibitory Purkinje cell synapses enhances gain modulation in the cerebellar nuclei

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