The fan mussel Pinna nobilis L. is the largest endemic bivalve in the Mediterranean Sea under strict protection. The aim was to determine the effects of anthropogenic activity on antioxidant and oxidative stress biomarkers in digestive gland of P. nobilis. Antioxidant enzyme activities and protein oxidation were significantly increased in mussels sampled in the impacted area. The anthropogenic activities induced a situation of oxidative stress in P. nobilis, resulting in an antioxidant response and in an increased protein oxidatio
