One of the most used cephalosporin in clinical practice is ceftriaxone. Anaphylaxis due to the
administration of ceftriaxone is considered a rare event. Here, we report a case of fatal
anaphylactic shock after the administration of ceftriaxone in a child who had tolerated the drug in
past exposures. The allergic pathogenesis is sustained by the clinical data (short time between
the inoculation of the drug and the onset of the symptoms; past exposure to the same molecule
and probable sensitization) and the postmortem examination findings (polivisceral congestion and
intense eosinophilia found in the histological examination)
