CAMPISI, Giuseppina

COMPILATO, Domenico

Dioguardi, M

Lo Muzio, L.

Santarelli, A

PubMed

Archivio istituzionale della ricerca - Università di Palermo

Case SeriesSalivary gland tumors in patientswith necrotizing sialometaplasia: a case seriesM. Dioguardi1, A. Santarelli2, D. Compilato3, G. Campisi3, L. Lo Muzio11Department of Sperimental and Clinical Medicine, University of Foggia, Italy; 2 Department of Specialistic and Odon-tostomatological Sciences, Polytechnic University of Marche, Ancona, Italy; 3 Department of Surgical, Oncologic andStomatologic Sciences, University of Palermo, ItalyNecrotizing sialometaplasia (NS) is a benign, reactive, necrotizing lesion that may involve minor salivary glands, and,more rarely, major salivary glands and mucoserous glands of the upper respiratory tract. To date, about 220 patientshave been reported in literature, harboring NS in the parotid gland, submandibular gland, incisive canal, lower lip,tongue, floor of mouth, retromolar area, mucoserous glands of the nasal cavity, maxilla, larynx and trachea1. The ma-jority of cases of NS, however, involve the hard and/or soft palate. Although benign and self-limiting, NS is significantbecause it might be clinically and histologically mistaken for malignancy2. Furthermore, NS may accompany tumorsof minor and major salivary glands3. In this series we reported 6 patients affected by NS associated with minor andmajor salivary gland tumours. 2 patients presented NS of the minor salivary glands of the palate, and had associatedneoplasms (pleomorphic adenoma and adenoid cystic carcinoma) at the same site. Four patients had NS of theparotid gland associated with epithelial-myoepithelial carcinoma, adenoid cystic carcinoma, Warthin’s tumor and on-cocytoma. Necrotizing sialometaplasia is a self-limited disease with spontaneous resolution in most cases; even if re-generation of the affected ducts and acini is usually incomplete, the healing process includes repair of both the ulcer-ation and regeneration of the damaged salivary tissue. During this regenerative process, the presence of ductal andacinar metaplasia, prominent nuclei, frequent mitotic figures and necrosis may lead to an incorrect diagnosis of ma-lignancy. Although infrequently, NS has in fact been reported to obscure an underlying neoplasm, thus resulting indelays in referral or treatment. This further stresses the importance of performing an appropriate biopsy and carefullymonitoring patients with NS of the minor salivary glands.References1. Pires FR, Chen SY, da Cruz Perez DE, de Almeida OP, Kowalski LP. Cytokeratin expression in central mucoepidermoid carci-noma and glandular odontogenic cyst. Oral Oncol 2004; 40(5):545.2. Abrams AM, Melrose RJ, Howell FV. Necrotizing sialometaplasia. A disease simulating malignancy. Cancer 1973; 32:130-135.3. Brannon RB, Fowler CB, Hartman KS. Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review ofthe literature. Oral Surg Oral Med Oral Pathol 1991; 72:317-325.16 Annali di Stomatologia 2013; Suppl. 2: 1-48Suppl.completo reimpag._4b_.  04/10/13  15:55  Pagina 16

Salivary gland tumors in patients with necrotizing sialometaplasia: a case series

https://iris.unipa.it/retrieve/handle/10447/87506/102050/salivary%20gland%20tumour.pdf

Salivary gland tumors in patients with necrotizing sialometaplasia: a case series

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