Oral comunication for American Society of Neuroradiology 45th Annual Meeting. Chicago, June 9-14 200

CARETTI, Vincenzo

CRAPARO, Giuseppe

Fariello G

GAGLIARDO, Cesare

Iaia, A

LAGALLA, Roberto

MIDIRI, Massimo

PALERMO PATERA, Giovanni

SPARACIA, Gianvincenzo

Texeida, M

Archivio istituzionale della ricerca - Università di Palermo

ASNR  2007: PROCEEDINGSCHICAGO, ILLINOIS2007JUNE 11 - 14, 2007HYATT REGENCY CHICAGOCHICAGO, ILLINOISAMERICAN SOCIETY OF NEURORADIOLOGYIncludes Interactive CD-ROM2007 PROCEEDINGSPLATINUM LEVELSILVER LEVELGOLD LEVELPROGRAM CONTRIBUTORSAn educational grant in support of the NER Foundation Symposium 2007: The Aging BrainBayer HealthCare Pharmaceuticals/NER FoundationFellowship in Basic Science ResearchAnnual Bayer HealthCare Pharmaceuticals OutstandingPresentation Award in General NeuroradiologyAnnual educational grant in support of theMaintenance of Certification (MOC) andSelf Assessment Modules (SAM)1 programming live and on the ASNR website(Formerly Berlex)1Programming is currently under review for Self Assessment Modules (SAM) credit through the American Board of Radiology (ABR) for approval.5642 Cover_wb:proceeding_concepts07  4/29/07  4:37 PM  Page 1Paper 85 Starting at 4:03 PM, Ending at 4:11 PM Comparison of Diffusion Tensor Imaging in SystemicLupus Erythematosus with and withoutNeuropsychiatric Symptoms: A Prospective Study ofApparent Diffusion Coefficient and FractionalAnisotropy Values in Different Regions of the Brain Williamson, J. A. · Petrou, M. · Foerster, B. · Gebarski, S. ·Cagnoli, P. · McCune, W. J. · Sundgren, P. C.University of MichiganAnn Arbor, MI PURPOSETo determine if significant differences in apparent diffusioncoefficient (ADC) and fractional anisotropy (FA) values indifferent gray and white matter regions of the brain exist inpatients with neuropsychiatric systemic lupus erythematosus(NPSLE) when compared to patients with systemic lupuserythematosus (SLE) without neuropsychiatric symptoms.MATERIALS & METHODSEight patients (aged 23-55 years, mean 44.8) with sympto-matic NPSLE and 15 patients with SLE without neuropsy-chiatric symptoms (aged 27-59 years, mean 44.1) were eval-uated. All subjects underwent routine brain MR imaging.Diffusion tensor imaging also was obtained using a single-shot spin-echo EPI technique along nine different directionswith a b-value of 1000 s/mm2. 50 mm2 volumes of interestwere placed in standardized normal-appearing gray andwhite matter regions within both hemispheres. ADC and FAmaps were generated, and ADC and FA values and standarddeviations were calculated. A two-sample t-test was used forstatistical analysis.RESULTSStatistically significant differences (p < 0.005) were found inboth ADC and FA values when comparing the NPSLEpatients to the nonneuropsychiatric SLE patients in the inter-nal capsule. Significant differences in FA values in the insu-lar cortex, orbitofrontal cortex, thalamus, and cingulate cor-tex and significant differences in ADC values in periaque-ductal gray matter also were noted when comparing the twopopulations.CONCLUSIONDTI can distinguish significant differences in FA and ADCvalues in several normal-appearing regions of the brain inNPSLE patients when compared to SLE patients withoutneuropsychiatric symptoms. These alterations may be basedon loss of tissue integrity and in part due to demyelination.Furthermore, these findings may in the future assist in thediagnosis of NPSLE, help distinguish between acute andchronic disease, play a role in monitoring disease progres-sion, and possibly help to further elucidate the pathogenesisof NPSLE. KEY WORDS: Lupus, neuropsychiatric, diffusion tensorimaging Paper 86 Starting at 4:11 PM, Ending at 4:19 PM Hippocampal and Amygdalar Volumes Changes in DrugAddicts: A Preliminary Study Sparacia, G.1 · Iaia, A.2 · Patera, G.1 · Texeida, M.2 · Midiri,M.1 · Lagalla, R.11University of Palermo, Palermo, ITALY, 2OPBG, Roma,ITALYPURPOSEHippocampal and amygdalar volumes changes in individualswith childhood traumatic histories, and stress-related psychi-atric condition including posttraumatic stress disorder(PTSD) have been reported. In addition, psychological stud-ies have shown correlation among alexithymia and traumat-ic experiences in drug addicts. The aim of this study was toassess hippocampal and amygdala volumes changes in asample of drug addicts with traumatic histories (neglect, sex-ual abuse or physical abuse) and in a control group matchedfor age and gender.MATERIALS & METHODSThree self-report were administered to two samples (7addicts and 7 normal adult): DES (Dissociative ExperienceScale), TSI-A (Trauma Symptom Inventory - Alternative),TAS-20 (The Twenty-Item Toronto Alexithymia Scale). MRimaging examinations were carried out with a 1.5T MRscanner by using an isotropic 3D SPGR sequence on thesagittal plane. Volumetric measurements of the hippocampusand the amygdala were performed by means of voxel-basedmorphometry method. Group differences in total volumeswere assessed by means of analysis of variance (ANOVA);correlation analysis was performed to assess correlationamong alexithymia, dissociation and trauma.RESULTSThe analysis of the correlations confirms the hypothesis of acorrelation among alexithymia, dissociation and trauma. Thedrug addicts group showed higher scores at the self-reporttests and smaller amygdala and hippocampus volumes thanthe control group.CONCLUSIONVolumetric reduction of the hippocampus and amygdala indrug addicts seems to be correlated with trauma and addic-tive behavior. KEY WORDS: Alexithymia, hippocampus, amygdala Paper 87 Starting at 4:19 PM, Ending at 4:27 PM Diffusion-Weighted Imaging and Apparent DiffusionCoefficient Evaluation of Necrotizing andNonnecrotizing Viral Encephalitis Sawlani, V.1 · Maurya, S.2 · Phadke, R.2 · Misra, U.21Morriston Hospital, Swansea, UNITED KINGDOM,2SGPGIMS, Lucknow, INDIA, 3SGPGIMS, Lucknow,INDIAPURPOSEThe study was performed to evaluate the role of Diffusionweighted imaging (DWI) in the diagnosis of Herpes simplex47Monday

Hippocampal and Amygdalar Volumes Changes in Drug
Addicts: A Preliminary Study

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Hippocampal and Amygdalar Volumes Changes in Drug Addicts: A Preliminary Study

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Archivio istituzionale della ricerca - Università di Palermo