BATTAGLIA, Salvatore

BELLIA, Maria

BELLIA, Vincenzo

Cannizzaro, F

GIARDINA, Annarita

Messina, M

MIDIRI, Massimo

SCICHILONE, Nicola Alessandro

TRIOLO, Giovanni

Archivio istituzionale della ricerca - Università di Palermo

-å"ELLIAå-å-ESSINAå&å#ANNIZZAROå.å3CICHILONEå3å"ATTAGLIAå!åGIARDINAå6å"ELLIA'å4RIOLOå-å-IDIRIå0ALERMOå0!	)4å0ALERMO)40ULMONARYåFUNCTIONALåANDåRADIOLOGICALåCORRELATIONSåOFåNUTRITIONALåSTATUSåANDåPHYSICALåACTIVITYINåSYSTEMICåSCLEROSISECR#6IENNAå*ANUARYåPage 1 of 6Pulmonary functional and radiological correlations ofnutritional status and physical activity in systemic sclerosisPoster No.: C-1555Congress: ECR 2011Type: Scientific ExhibitAuthors: M. Bellia1, M. Messina2, F. Cannizzaro1, N. Scichilone2, S.Battaglia2, A. giardina2, V. Bellia2, G. Triolo2, M. Midiri1; 1Palermo(PA)/IT, 2Palermo/ITKeywords: Connective tissue disorders, CT-High Resolution, RespiratorysystemDOI: 10.1594/ecr2011/C-1555Any information contained in this pdf file is automatically generated from digital materialsubmitted to EPOS by third parties in the form of scientific presentations. Referencesto any names, marks, products, or services of third parties or hypertext links to third-party sites or information are provided solely as a convenience to you and do not inany way constitute or imply ECR's endorsement, sponsorship or recommendation of thethird party, information, product or service. ECR is not responsible for the content ofthese pages and does not make any representations regarding the content or accuracyof material in this file.As per copyright regulations, any unauthorised use of the material or parts thereof aswell as commercial reproduction or multiple distribution by any traditional or electronicallybased reproduction/publication method ist strictly prohibited.You agree to defend, indemnify, and hold ECR harmless from and against any and allclaims, damages, costs, and expenses, including attorneys' fees, arising from or relatedto your use of these pages.Please note: Links to movies, ppt slideshows and any other multimedia files are notavailable in the pdf version of presentations.www.myESR.orgPage 2 of 6PurposeSystemic Sclerosis (Ssc) or scleroderma is a connective tissue disease of unknownorigin.It may affect skin, as well as blood vessels and internal organs including lungs.In SSc patients physical activity limitation is often observed. It is unclear whether changesin nutritional status contribute to alter physical performance.The present study was aimed at exploring the physical and nutritional status of patientswith SSc.Methods and MaterialsSAMPLE:- 27 subjects with SSc;- 11 age- and sex-matched healthy volunteers.MEASUREMENTS: The lung involvement was evaluated by:- Pulmonary function tests (spirometry and lung diffusion capacityfor CO)- HRCT (the degree of radiological involvement was evaluated by Warrick score, a semi-quantitative method based on the assessment of severity and extent of different typesof lesions).The nutritional status and the body composition were evaluated by:- Mini Nutritional Assessment (MNA) questionnaire- Bio Impedance Assessment (BIA)To evaluate physical activity subjects wore, for one week, a multisensor device: -Sensewear Armband (see figure 1)Page 3 of 6Fig.: Fig.1 The armband deviceReferences: M. Bellia; DIBIMEF sezione di scienze radiologiche, Università degli Studidi Palermo, Palermo (PA), ITALYThe multi-sensor device used five sensors:Page 4 of 6- two accelerometers;- skin temperature;- near body temperature/heat flux;- galvanic skin resistance.The SenseWear Armband allowed to measure:- Total energy expenditure (TEE);- Active energy expenditure (AEE);- Physical activity duration (PAD).STATISTICAL ANALYSIS: Data are presented as mean±SD. Differences betweengroups were evaluated by Mann-Whitney test. Correlation between variables wereevaluated by Spearman's rho. Probability values of p<0.05 were considered to bestatistically significant.ResultsIn the SSc group, spirometry was normal (FEV1 % pred = 97.5 ± 14%; FVC % pred =100 ± 12.8%). The diffusing capacity of the lung for CO (DLCO) was significantly lower inSSc group than in controls (61 ± 17% pred. vs 88 ± 4.7% pred., respectively; p=0.002).The DLCO correlated with HRCT derived Warrick score of radiologic involvement (r =-0.47; p = 0.029).The fat-free mass (FFM) was significantly lower in patients compared to controls (FFM=46.8±7.6 Kg vs 53.6 ± 6.3 Kg; p=0.01) (fig. 2)Page 5 of 6Fig.: Fig.2 Diagram showing the difference in FFM between cases and controlsReferences: M. Bellia; DIBIMEF sezione di scienze radiologiche, Università degli Studidi Palermo, Palermo (PA), ITALYPhysical activity duration (PAD) was significantly lower in patients than in controls (PAD=243 ± 145 min. vs 397 ± 142 min.; p=0.004) (fig. 3).Fig.: Fig.3 Diagram showing the difference in PAD between cases and controlsPage 6 of 6References: M. Bellia; DIBIMEF sezione di scienze radiologiche, Università degli Studidi Palermo, Palermo (PA), ITALYIn the whole sample, DLCO was correlated with both PAD (r = 0.39; p = 0.015) and withFFM (r = 0.41; p = 0.011). On the contrary, these correlations were not observed for HRCTderived Warrick score. Moreover, PAD and FFM were correlated (r = 0.48; p = 0.002).ConclusionAlthough SSc patients were in apparently good nutritional and spirometric condition,they showed lower FFM compared to controls. This, together with the correlationbetween FFM and PAD, could account for physical activity impairment, exercise inducedbreathlessness and poor quality of life often shown by SSc patients . On this basis furtherstudies are needed to confirm this relationship and to explore the possibility that physicalrehabilitation programs become a part of treatment strategy in SSc patients.References• Naidich DP, Webb VR, Grenier PA, Harkin TJ, Gefter WB. Imaging of theairways. Functional and radiological correlations. Lippincott, Williams &Wilkins, Philadelphia 2005• Camiciottoli G, Orlandi I, Bartolucci M, Meoni E, Nacci F, Diciotti S, BarcaroliC, Conforti ML, Pistolesi M, Matucci-Cerinic M, Mascalchi M. Lung CTdensitometry in systemic sclerosis: correlation with lung function, exercisetesting, and quality of life. Chest. 2007 Mar;131(3):672-81.• Du Bois RM, Richeldi L. Interstitial lung diseases. European RespiratoryMonograph 46, 2009• Bellia M, Cannizzaro F, Scichilone N, Riili M, Triolo G, Midiri M, Lagalla RHRCT and scleroderma: semiquantitative evaluation of lung damage andfunctional abnormalities. Radiol Med. 2009 Mar;114(2):190-203.Personal Information

Pulmonary functional and radiological correlations of nutritional status and physical activity in systemic sclerosis

https://iris.unipa.it/retrieve/handle/10447/71545/67850/Bellia_M_ESR-poster%202011.pdf

Pulmonary functional and radiological correlations of nutritional status and physical activity in systemic sclerosis

Abstract

Similar works

Full text

Available Versions

Archivio istituzionale della ricerca - Università di Palermo