BARONE, Giampaolo

TERENZI, Alessio

Archivio istituzionale della ricerca - Università di Palermo

       11th International Symposium on Applied Bioinorganic Chemistry    Barcelona, Spain   December 2nd  – 5th, 2011    International Advisory Committee  David R. Williams (Chairman, Cardiff, UK) Jan Reedijk (Co-chairman, Leiden, NL) Ettore Benedetti (Naples, IT) Franc Meyer (Goettingen, GE) Sue Berners-Price (Nathan, AU) Mikio Nakamura (Tokyo, JP) Mercè Capdevila (Barcelona, SP) Giovanni Natile (Bari, IT) Maria Armenia Carrondo (Lisbon, PT) Chris Orvig (Vancouver, CA) John H. Dawson (SC, US) Joâo Costa Pessoa (Lisboa, PT) Nick Hadjiliadis (Ioannina, GR) Enrico Rizzarelli (Catania, IT) Liang-Nian Ji (Guangzou, CN) Peter Sadler (Warwick, UK) Nina Kasyanenko (St. Petersburg, RU) Athanasios Salifoglou (Thessaloniki, GR) Tamas Kiss (Szeged, HU) Andrea Scozzafava (Florence, IT) Bernhard Lippert (Dortmund, DE) Helmut Sigel (Basel, CH) Guillermo Mendoza-Díaz (Guanajuato, ME) Imre Sóvágó (Debrecen, HU)     Local Organizing Committee  Mercè Capdevila (Chair, UAB, Barcelona) Olga Iranzo (Secretary, ITQB, Oeiras)  Sílvia Atrian (UB, Barcelona) Gabriel Aullón (UB, Barcelona) Gotzone Barandika (UPV/EHU,Vitoria/Gasteiz) Roger Bofill (UAB, Barcelona) Amparo Caubet (UB, Barcelona) José M. Domínguez-Vera (UGR, Granada) Antonio Donaire (UM, Murcia) Virtudes Moreno (UB, Barcelona) Òscar Palacios (UAB, Barcelona) Joan Suades (UAB, Barcelona)   11th International Symposium on Applied Bioinorganic Chemistry Barcelona 2011 P-133 DNA Binding and Biological Activity of  Transition Metal Complexes A. Terenzi,1 G. Barone1 1 Università degli Studi di Palermo, Dipartimento di Chimica ‘‘S. Cannizzaro’’, 90128-Palermo (Italy);  alessio.terenzi@unipa.it  The principal aim of our work is mostly focused on the synthesis of novel transition metal complexes able to non-covalently recognize DNA, using Schiff base, oxadiazole and dipyrydil derivatives as ligands. The coordination geometries of the molecules obtained range from tetracoordinate mononuclear complexes to binuclear metallo-supramolecular assemblies. For instance, the DNA binding of NiII, CuII and ZnII complexes of Salphen[1,2] and oxadiazole[3,4] ligands mainly occurs by intercalation and groove-binding for the former and the latter, respectively. Moreover, CuII and ZnII heteroleptic complexes of dipyrido[3,2-a:2',3'-c]phenazine (dppz) and amino acids are strong DNA-intercalators. Finally, a 2,7-diazapyrenium binuclear PtII rectangular box-shaped metallacycle[5] is a major-groove binder that induces DNA coiling. Interestingly, the DNA binding properties of the complexes find a positive feedback in their in vitro biological activity. For example, CuII complexes of both 1,2,4- and 1,3,4-oxadiazole ligands as well as the PtII metallacycle reduce the vitality of different human cancer cell lines in a dose- and time-dependent manner.  Acknowledgements Financial support from the C.I.R.C.M.S.B. (Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici) is gratefully acknowledged. !References [1] G. Barone, N. Gambino, A. Ruggirello, A. Silvestri, A. Terenzi, V. Turco Liveri, J. Inorg. Biochem. 2009, 103, 731-737.  [2] G. Barone, A. Ruggirello, A. Silvestri, A. Terenzi, V. Turco Liveri, J. Inorg. Biochem. 2010, 104, 765-773  [3] A. Terenzi, G. Barone, A. Palumbo Piccionello, G. Giorgi, A. Guarcello, A. Pace, Inorg. Chim. Acta 2011, 373, 62-67. [4] A. Terenzi, G. Barone, A. Palumbo Piccionello, G. Giorgi, A. Guarcello, P. Portanova, G. Calvaruso, S. Buscemi, N. Vivona, A. Pace, Dalton Trans. 2010, 39, 9140-9145. [5] V. Blanco, M.D. Garcia, A. Terenzi, E. Pia, A. Fernandez-Mato, C. Peinador, J.M. Quintela, Chem. Eur. J. 2010, 16, 12373-12380. 

DNA Binding and Biological Activity of Transition Metal Complexes

https://iris.unipa.it/retrieve/handle/10447/64948/45256/2011_ISABC11_terenzi.pdf

DNA Binding and Biological Activity of Transition Metal Complexes

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Archivio istituzionale della ricerca - Università di Palermo