Myo-Inositol (MI) is involved in several aspects of
human reproduction. Elevated concentrations of
myo-inositol in human follicular fluids, in fact, seem
to play a positive role in follicular maturity, since to
represent a possible marker of good oocyte quality.
Nevertheless its positive role in PCOS patients is a
consequence of a defect in the insulin signaling (inositol-
containing phosphoglycan mediators) pathway
that seems to be implicated in the pathogenesis of insulin
resistance.
The aim of this study was to analyze the effect of
myo-inositol supplementation to “standard” therapy
in PCOS women and in “poor responders”, submitted
to In Vitro Fecundation (IVF) cycles.
In particular, we have investigated its influence on
ovarian response to hormonal stimulation and on
oocytes quality. Preliminary results of our study, anyway,
appear in contrast with results of previous studies;
supplementation with MI, in fact, do not seem to
improve the response neither in PCOS patients nor in
poor responders