Analysis of treatment and results of the patientsenrolled in the Italian TCG-98 Study, still open and comparison of data with those of the previous Studt TCG-9

Alaggio, R.

Cecchetto, G.

Cesca, E.

Inserra, A.

LO CURTO, M.

Martin, A.

Siracusa, F.

LO CURTO, Margherita

MARTIN,A

ALAGGIO,R

CESCA,E

SIRACUSA, Fortunato

INSERRA,A

CECCHETTO,G

Archivio istituzionale della ricerca - Università di Palermo

Pediatr  Blood  Cancer  2004;43:335–336Surgery In Malignant Germ Cell Tumours Of Chilhood. Results Of The Second Italian Cooperative Study-Tcg-98P. Dall’Igna1, M. Lo Curto2, A. Martin1, R. Alaggio3, E. Cesca4,  A. Inserra4, G. Cecchetto1 and F. Siracusa2University-Hospital of Padova,  1Pediatric Surgery, 3Pathology, Padova, Italy2University of Palermo, Istituto Materno Infantile, Palermo, Italy4Bambino Gesù Hospital, Pediatric Surgery, Roma, ItalyAIMAnalysis of treatment and results of the patients enrolled in the Italian TCG-98 Study, still open, and comparison of data with those of the previous Study TCG-91.Materials and Methods. 25 valuable patients (11M, 14F, median age 20,5months), enrolled from January 1998 to March 2003, were analyzed. The tumors were gonadal in 16 patients (10 testis, 6 ovary), extragonadal in 9 (7 sacrococcigeal, 2 retroperitoneal); seminomatous in 3 (ovarian dysgerminoma), nonseminomatous in 22 (12 Yolk Sac Tumor, 9 Mixed, 1 Embryonal Carcinoma). The therapeutic guidelines included for ST-1 (completely excised, no local extension) chemotherapy (CT) only in case of persisted positive markers; ST-II (completely excised, local extension) and ST-IIIa (microscopical residual, negative lymph nodes) CT with carboplatin-VP16; ST IIIb and IIIc (macroscopical residues or biopsy) CT with Carcoplatin-VP16-dactinomicine-ifosfamide + Surgery; ST-IV Ct + Surgery of primary tumor/metastases.Results. ST-I:    13 pz: 11 (10 gonadal, 1 retroperitoneal) complete remission (CR) (FU 12-72 months), 1 (testis) alive with disease (AWD) after treatment for local relapse (LR) occurred 7 months after diagnosis.1 (retroperitoneal) dead (DOD) 35 months after diagnosis because of LR + metastases.ST-II: 1 pz sacrococcigeal: CR (FU 17 months).  ST-IIIa: 1 pz sacrococcigeal: CR after LR treated with a second operation (FU 23 months).ST-IIIb: 2 pz  ovary: CR (25,29 months).ST-IIIc: 3 pz: 2 ovary in CR (FU 9,22) and 1 sacrococcigeal DOD 22 months after re-operation for LR.ST-IV: 5 pz: 2 sacrococcigeal CR (FU 27,39), 1 testis and 1 sacrococcigeal AWD (FU 18,43), 1 sacrococcigeal DOD 13 months after diagnosis.Conclusions.No major discordances between guidelines and surgical approaches adopted. Favourable outcome for: Complete or with microscopical residual initial excision, seminomatous tumors, gonadal site.Delayed surgery allowed local control. AFP at diagtnosis has prognostic value: 8000 mG/L in CR patients, 80.000 in DOD patients.Comparison between TCG-91 (data already published) and TCG-98 Studies: lower registration, similar overall survival, better prognosis for ST-IV.  

SURGERY IN MALIGNANT GERM CELL TUMORS OF CHILDHOOD. RESULTS OF THE SECOND ITALIAN COOPERATIVE STUDY TCG 98

https://iris.unipa.it/retrieve/handle/10447/5479/125795/SURGERY%20IN%20MALIGNANT%20GERM%20CELL%20TUMOURS%20RESULTS%20OF%20THE%20SECOND%20ITALIAN%20COOPERATIVE%20STUDY%20Tcg%2098.pdf

SURGERY IN MALIGNANT GERM CELL TUMORS OF CHILDHOOD. RESULTS OF THE SECOND ITALIAN COOPERATIVE STUDY TCG 98

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Archivio istituzionale della ricerca - Università di Palermo