Fitzpatrick, Veronica, DrPH, MPH

Ozoani-Lohrer, Osondi, MS

Shields, Maureen, MPH

English

SHARE @ Advocate Health - Midwest

Community member views of clinical trials in a Midwestern Healthcare System; A Mixed-Methods StudyOsondi Ozoani-Lohrer, MS1; Maureen Shields, MPH1; Veronica Fitzpatrick, DrPH, MPH11Advocate Aurora Research InstituteImportance of Clinical Trials• Assess new treatments or procedures • Important for finding out if a treatment is safe and effective for diverse groups of people2Underrepresentation of Minority Groups in Clinical Trials– Racial and ethnic minorities, older adults, and women often underrepresented3– Leads to reduced generalizability and insufficient access to new treatments1,3,5 – Leads to disparities in health outcomes3-4BackgroundPurpose• Identify barriers to improving diversity in clinical trials at AAH• Better understand community member perspective on clinical trial diversity• Propose community-derived solutions to improve diversity in clinical trials • Suggest implementable changes to improve diversity in clinical trialsA Mixed-Methods StudyRECRUITMENT USING QR CODED FLYERS AT COMMUNITY HEALTH EVENTSPARTICIPANTS SELECTED INTERVIEW/SURVEYINTERVIEWS WERE CONDUCTED BY STUDY TEAM OR SURVEYS WERE OFFERED IN REDCAPTHEMATIC ANALYSIS USING DEDUCTIVE CODING WAS USED TO APPLY RESPONSE CODES FOR BARRIERS AND SOLUTION SOCIAL SUPPORT THEORY CONSTRUCTSIdentify as person of Color AND/OR have insight due to cultural differences unrelated to race or ethnicityOver 18 years old75 Community Members from Illinois and Wisconsin Participated in the StudyParticipants and Eligibility MethodsRESULTSHeat Map of Proportions of Perceived Barriers Increasing Diversity in Clinical Trials Participation as Identified by Community MembersCommunity Members (N=75)Lack of information/awareness 69.30%Lack of trust in care team 65.30%General hesitance of research 48.00%Anxiety about participating 44.00%Logistics 42.70%Insurance issues 30.70%Not willing to go through additional procedures and treatments 28.00%Anxiety about current diagnosis 28.00%Not eligible due to medical conditions 18.70%Believes current treatment is sufficient 16.00%Language barriers 2.70%Educate patients on research opportunities 94.60%Improve trust between the healthcare system and the communities served 94.60%Increase the healthcare system's presence in the community 89.30%Provide more education on diseases and treatments 82.60%Improve diversity of clinical site staff in the healthcare system 64.00%Provide more time for staff to educate patients on clinical trials 58.60%Include more diverse populations in marketing materials 46.70%Improve access to interpreter and/or translation services within healthcare system 45.30%Community Members (N=75)Heat Map of Proportions of Perceived Solutions to Increasing Diversity in Clinical Trials Participation as Identified by Community MembersThematic Analysis Social Support Theory ConstructsSummaryTop 3 Barriers to ParticipationLack of information/ awareness at 69.3%Lack of trust in care team at 65.3%General hesitance of research at 48.0%Top 3 Solutions ProposedEducating patients on research opportunities and improve trust between healthcare system and the community served both at 94.6%Increase the healthcare system’s presence in the community at 89.3% Provide more education on disease and treatments at 82.6% ConclusionTangible Implementable Steps• Make research-related recruitment materials more diverse• Increase awareness and understanding of available clinical trials• Improve communication between providers and patients• Provide effective translation services for non-English speakers“Community trust in research from a healthsystem can be dependent upon their trust in the health system.”       - Cheryl LefaiverDirector, Center for Child and Family Research        Advocate Aurora Research Institute at HCSRN April 10, 2024 – Translation of FindingsWhere are we now?References1. Caplan A, Friesen P. Health disparities and clinical trial recruitment: Is there a duty to tweet? PLoS Biol. 2017;15(3):4-7. doi:10.1371/journal.pbio.20020402. Carson P, Ziesche S, Johnson G, Cohn JN. Racial differences in response to therapy for heart failure: Analysis of the Vasodilator-Heart Failure Trials. J Card Fail. 1999;5(3):178-187. doi:10.1016/S1071-9164(99)90001-53. Clark LT, Watkins L, Piña IL, et al. Increasing Diversity in Clinical Trials: Overcoming Critical Barriers. Curr Probl Cardiol. 2019;44(5):148-172. doi:10.1016/j.cpcardiol.2018.11.0024. Langford AT, Resnicow K, Dimond EP, et al. Racial/ethnic differences in clinical trial enrollment, refusal rates, ineligibility, and reasons for decline among patients at sites in the National Cancer Institute’s Community Cancer Centers Program. Cancer. 2014;120(6):877-884. doi:10.1002/cncr.284835. Wendler D, Kington R, Madans J, et al. Are racial and ethnic minorities less willing to participate in health research? PLoS Med. 2006;3(2):0201-0210. doi:10.1371/journal.pmed.0030019

Community Members’ View of Clinical Trials in a Midwestern Healthcare System: A Mixed-Methods Study

https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1231&context=sciday

Community Members’ View of Clinical Trials in a Midwestern Healthcare System: A Mixed-Methods Study

Abstract

Similar works

Full text

Available Versions

SHARE @ Advocate Health - Midwest