The effect of fasciolosis invasion on the protein-synthesizing function of the liver in cows sensitized by atypical mycobacteria and the influence of corrective fac-tors

Abstract

Among the most common parasitic pathologies in ruminants, trematode diseases, particularly fascioliasis, occupy a leading position in terms of severity and the economic losses they cause. Both domestic and foreign literature also confirm that, alongside fascioliasis in cattle, mycobacteriosis has become widely spread. Therefore, the study aimed to determine the effect of Lipointersil and Cloverm A on the protein-synthesizing function of the liver in cows with experimental fascioliasis sensitized by atypical mycobacteria. Animals in the experimental groups were intramuscularly administered Cloverm A at 0.5 ml per 10 kg of body weight and Lipointersil at 10 ml per animal. The liposomal preparation “Lipointersil” contains interferon and the fruits of the milk thistle. It was established that in cows with fascioliasis, sensitized by mycobacteria, the protein-synthesizing function of the liver is suppressed, which is manifested by a 12.7% decrease in total protein levels, a 28.2 % decrease in albumin levels, and a 16.3 % increase in globulin levels in their blood. The preparations “Cloverm A” and “Lipointersil” contributed to the restoration of the liver's protein-synthesizing function, as Cloverm A causes the death of Fasciola. After the body is cleared of parasites, toxins no longer affect the liver, and inflammatory processes subside. Lipointersil, which contains milk thistle fruits, stimulates protein synthesis and normalizes liver function. Therefore, for effective treatment of cows with fascioliasis sensitized by atypical mycobacteria and to reduce side effects on the immune, antioxidant systems, and metabolism, it is recommended to use Cloverm A at a dose of 0.5 ml per 10 kg of body weight and Lipointersil at a dose of 10 ml per animal