International audienceThere are still unmet medical needs in the treatment of glioblastoma, themost common and the most aggressive glioma of all brain tumors. Here, we foundthat O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue.In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylatGD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Takentogether, these results indicate that O-acetylated GD2 represents a novel antigen forimmunotherapeutic-based treatment of high-grade gliomas
