Interaction is an important key in any learning process. It's result in promoting students' achievement in learning and influence students, instructors and the learning experiences. Interaction is meaningful when interaction gives an impact on learners' intellectual development. The definition of meaningful interaction is related to the learning theories of all learning environments. The essential of interaction is also dependent upon the contexts in which interaction occurs, in a faceto- face situation or online environments and of course, every interaction in an online learning environment does not have an influence on increased learning. Therefore, the aim of this concept paper is to design meaningful interaction in Facebook based on the theory of learning and the strategies that could contribute to begin the understanding of the nature of interaction and learning processes it enables. Hence, the theory and principle selected to be applied in real study to investigate the effectiveness of the design. Based on the results, we will hopefully begin to understand clearly the nature of interaction and learning processes it enables. Based on this understanding, we can better manage and facilitate the interaction process as well as design meaningful interaction in online learning environments. It has several significant importance to certain entities including students, instructors, lecturers, and the Ministry of Education in Malaysia (MOE). This guideline might be useful for educators to generate meaningful learning interaction in social learning environment such as Facebook
