CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
research
A novel thiazolidine compound induces caspase-9 dependent apoptosis in cancer cells
Authors
R. Cetin Atalay
I. Durmaz
+3 more
J. Herscovici
F. E. Onen Bayram
D. Scherman
Publication date
1 September 2012
Publisher
'Elsevier BV'
Doi
Cite
Abstract
Cataloged from PDF version of article.The forward chemogenomics strategy allowed us to identify a potent cytotoxic thiazolidine compound as an apoptosis-inducing agent. Chemical structures were designed around a thiazolidine ring, a structure already noted for its anticancer properties. Initially, we evaluated these novel compounds on liver, breast, colon and endometrial cancer cell lines. The compound 3 (ALC67) showed the strongest cytotoxic activity (IC50 ∼5 μM). Cell cycle analysis with ALC67 on liver cells revealed SubG1/G1 arrest bearing apoptosis. Furthermore we demonstrated that cytotoxicity of this compound was due to the activation of caspase-9 involved apoptotic pathway, which is death receptor independent. © 2012 Elsevier Ltd. All rights reserve
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Bilkent University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repository.bilkent.edu.tr:...
Last time updated on 12/11/2016