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research article
Preliminary study on the mechanism of reading recovery in a pure alexia by using functional MRI
Authors
唐一源
孙伟建
+5 more
封世文
张武田
李德军
翁旭初
马林
Publication date
1 January 2004
Publisher
Abstract
目的 利用磁共振功能成像 (fMRI)技术观察阅读功能恢复过程中脑功能的变化 ,为阐明阅读和语言功能恢复机制提供实验依据。方法 采用fMRI对 1例汉语纯失读症患者在其发病后4 5d和 130d分别进行扫描。在扫描过程中要求病人判断是否认识所呈现的 3类汉字。经后处理获得脑激活图 ,并对 2次实验所观察到的脑激活部位和激活体积等进行比较。结果 第 1次实验显示Broca区、Wernicke区和右侧纹外区等被激活。而在第 2次实验中 ,除上述区域仍被激活外 ,病灶周围的左侧纹外区也见显著激活 ,且右侧纹外区的激活体积比首次实验增大了约 2倍。结论 左侧纹外区皮层是阅读功能的关键脑区之一。阅读功能的恢复既可由对侧相应脑区代偿 ,也可由病灶同侧脑区重组 ,这 2种机制可以并存。</p
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Last time updated on 11/06/2025