令和6年度 京都大学化学研究所 スーパーコンピュータシステム 利用報告

Wu, Junyi

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令和 6年度 京都大学化学研究所スーパーコンピュータシステム利用報告書巨大ウイルスの遺伝子獲得にはウイルス間の遺伝子転移が大きく寄与しているGene Transfer Among Viruses Substantially Contributes to Gene Gain of Giant Viruses The Ogata lab, Chemical Life Science, Bioinformatics Center, Junyi Wu 研究成果概要The phylum Nucleocytoviricota comprises a diverse group of double-stranded DNA viruses that display a wide range of gene repertoires. Although these gene repertoires determine the characteristics of individual viruses, the evolutionary processes that have shaped the gene repertoires of extant viruses since their common ancestor are poorly characterized. In this study, we aimed to address this gap in knowledge by using amalgamated likelihood estimation, a probabilistic tree reconciliation method that infers evolutionary scenarios by distinguishing origination, gene duplications, virus-to-virus horizontal gene transfer (vHGT), and gene losses. We analyzed over 4,700 gene families from 195 genomes spanning al known viral orders. The evolutionary reconstruction suggests a history of extensive gene gains and losses during the evolution of these viruses, notably with vHGT contributing to gene gains at a comparable level to duplications and originations. The vHGT frequently occurred between phylogenetically closely related viruses, as well as between distantly related viruses with an overlapping host range. We observed a pattern of massive gene duplications that followed vHGTs for gene families that was potentially related to host range control and virus-host arms race. These results suggest that vHGT represents a previously overlooked, yet important, evolutionary force that integrates the evolutionary paths of multiple viruses and affects shaping of Nucleocytoviricota virus gene repertoires. 発表論文（謝辞あり）Junyi Wu, Lingjie Meng, Morgan Gara, Hiroyuki Hikida, Yusuke Okazaki, Hisashi Endo, Hiroyuki Ogata, Gene Transfer Among Viruses Substantially Contributes to Gene Gain of Giant Viruses, Molecular Biology and Evolution, Volume 41, Issue 8, August 2024, msael 61, ~10.1093/molbev/msael 61 -42-

Gene Transfer Among Viruses Substantially Contributes to Gene Gain of Giant Viruses

https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/293932/1/scr_2025_42.pdf

Gene Transfer Among Viruses Substantially Contributes to Gene Gain of Giant Viruses

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