Bassiouny, Marwa*

Sprague, Lisa D.

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ESKAPE Pathogens in Germany: An overviewMarwa Bassiouny and Lisa D. SpragueFriedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses, Jena, GermanyBackground➢ Antimicrobial resistance (AMR) is a major global health threat increasing at an alarming rate.➢ Among the leading causes of nosocomial infections and AMR are the so-called ESKAPE pathogens, which are Enterococcus (E.)faecium, Staphylococcus (S.) aureus, Klebsiella (K.) pneumoniae, Acinetobacter (A.) baumannii, Pseudomonas (P.) aeruginosa, aswell as Enterobacter species.References• Wareth G, Sprague, LD, Neubauer H and Pletz MW. 2021. Klebsiella pneumoniae in Germany: An overview on spatiotemporal distribution and resistance development in humans. Ger. J. Microbiol. 1 (1): 16-25.https://doi.org/10.51585/gjm.2021.0004• Wareth G, Brandt C, Sprague LD, Neubauer H, Pletz MW. 2020. Spatio-Temporal Distribution of Acinetobacter baumannii in Germany-A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000-2018).Microorganisms. 6;8(3):375. doi: 10.3390/microorganisms8030375.Contact: Marwa Bassiouny   marwa.bassiouny@fli.deEmergence of antimicrobial resistance genes in A. baumannii in Germany (1991-2018)Emergence of antimicrobial resistance genes in K. pneumoniae in Germany                    (2009-2020) Summary➢ ESKAPE pathogens have been isolated from humans, animals, hospital environments, and veterinary clinics, as well as from foodand environmental samples in the majority of the German federal states.➢MDR isolates of ESKAPE pathogens harbour several resistant determinants mediating resistance to aminoglycosides, tetracyclines, cephalosporins and fosfomycin have been isolated from horses, dogs, cats, cattle, pigs, rabbits, poultry farms, milk samples and wastewater in different localities in Germany.➢ The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options of severe infections,has increased the burden of disease, and has increased death rates due to treatment failure.➢ Large-scale genomic surveillance of strains from different resources is required in order to understand the mechanisms of resistance and to strengthen the one health concept.➢ A typical feature of ESKAPE pathogens is their rapid spread in communities and hospitals and their association with high mortalities.➢ ESKAPE pathogens are intensively investigated in human medicine, but they are still under represented in veterinary medicine and environmental health sectors.➢ Global efforts are required to restrict the spread of ESKAPE pathogens and to develop novel therapies.~ESKAPEPATHOGENSStaphylococcusaureusAcinetobacterbaumanniiPseudomonasaeruginosaEnterococcusfaeciumEnterobacterspeciesKlebsiella pneumoniaeView publication stats

ESKAPE Pathogens in Germany: An overview: [Poster]

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ESKAPE Pathogens in Germany: An overview: [Poster]

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