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Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

Abstract

In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast, which is due to the higher endocytic activity of tumor cells comparing to normal cells. In this way, we are demonstrating that biosynthesized Ag NPs can be an alternative for the treatment of tumors.Fil: Ortega, Francisco Gabriel. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Fernández, Jorge Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Serrano, Maria J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Sanz Ferramola, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Diaz Mochón, Juan J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Lorente, José Antonio. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentin

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