International audienceIn France, a national campaign to improve antibiotic use was launched in 2002. In 2003, and 2010 respectively were introduced the 7-valent pneumococcal conjugate vaccine (PCV7) and PCV13 for children < 2 years. To evaluate trends in antibiotic resistance and changes in circulating serotypes of Streptococcus pneumoniae (Spn) isolated in middle ear fluid in children (< 16 years) during acute otits media (AOM) over a 10 years period (2001-2011), data from the French Pneumococcus Network, a national survey program, were analysed