Supplemental Figure S3 from Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method

Abstract

Supplemental Figure S3: shRNA mediated silencing of p16Ink4a or Trp53 leads to decreased survival. Kaplan-Meier survival analysis shows a significant decrease in survival of animals that were injected with Kras-shRNAp16Ink4a-PDCs (median survival 109 days, p=0.04) or Kras-shRNA-Trp53-PDCs (median survival 125.5 days, p=0.038)</p