A Quantitative study was done to analysis Quality of Life (QOL) between Iranian and Malay postgraduate students in Universiti Sains Malaysia (USM). For this purpose, data were elicited from 35 Iranian and 35 Malay students through a WHOQOL-BREF questionnaire. WHOQOL-BREF has 26 questions and four broad domains namely: Physical health, Psychological, Social Relationships and Environmental domains. Sample characteristics were determined using means and standard deviation and Independent t-tests uses to consider differences for the domain of QOL in two groups of postgraduate students. The participants were of the same language proficiency. Results showed that the internal consistencies (Cronbach alpha) in physical health, psychological, social Relationships and environmental domains are 0.74, 0.79, 0.61, and 0.72, respectively. Moreover, domains are evaluated 60.5 ±10.6, 62.9±11.3, 64.5±14.5, 60.2±10.1 for Malay postgraduate students, and 66.5±13.5, 64.5±16.1, 63.6±17.7, 59.4±13.4 for Iranian postgraduate students, respectively. According to these results, the physical domain is only significant between two groups (P<0.008). Furthermore, our study indicates QOL is in the middle level (50 – 75 %) for all postgraduate students. This study provides comprehensive information that can be applied to improve education quality in national and international students