Background and aim: Protein C is one of the important components in haemostasis system and its deficiency could increase the risk of thromboembolic events. This deficiency is seen in 0.2% of the general population. In this case report we present a 3-day old neonate with an echymosis in her left thigh. Case presentation: A female neonate was visited regards to an echymotic lesion in her left thigh and a lighter one in the right which was present at birth. In her laboratory tests, protein C reported 17% while her parents had normal level. She was treated with antithrombotics and level of protein C elevated to 73% at discharge. Conclusion: Clinical manifestations of protein C deficiency could be severe and life threatening, so quick and careful management is needed
