Introduce: Postoperative nausea and vomiting (PONV) still is the most big problem event encountered in the PACU (Post Anesthesia Care Unit), despite advances in prevention and treatment. The incidence of PONV has remained high and has a major negative impact on patient satisfaction about the overall surgical experience. Method: In double-blind, clinical trial, 104 patients were undergoing cesarean section was randomizing into two groups: Group P (100μg Phenylephrine) and Group E (6μg Ephedrine). We compared the Vomiting parameters between the two groups. Result: Patients in the recovery were compared in 2 groups regarding occurrence of vomiting that no statistical difference between two group (P >0.05). The results show that vomiting was seen in ASA1, and in ASA2 no vomiting was observed. The incidence of vomiting was 2 patients in young group and 1 patient in middle-aged group. The incidence of vomiting was 2 patients in slim group, 1 in moderate group and no sign of vomiting has been seen in the obese group. Conclusion: We conclude that ephedrine is the best drug for antiemetic prophylaxis before cesarean surgery based on cost and lack of side effects
