New chiral nitrones as precursors of \alpha,\alpha-disubstituted amino-acids, according to the SRS principle

Abstract

The preparation of new enantiopure cyclic nitrones based on the 1-oxy-2,3-dihydro-imidazol-4-one ring is described. Addition of arylmagnesium or alkynylzinc reagents to these nitrones can be achieved with total enantio- and diastereoselectivity, leading to α, α-disubstituted amino-acids precursors