Addition of functional vinylzinc reagents to nitrones: synthesis of (E)-N-allylhydroxylamines and their rearrangement into (E)-O-allylhydroxylamines

Abstract

International audienceThe vinylzinc reagents derived from hydrozirconation of alkynes and transmetallation add readily to nitrones to yield pure (E)-N-allyl-hydroxylamines; some of those rearrange into O-allyl-hydroxylamines