Dépôt prioritaire : brevet US provisoire n° 61/145,158 déposé le 16/01/09. Extension Europe le 03/2010.The invention relates to processes for coating a surface with a crosslinked polyelectrolytes multilayer film incorporating a protein, preferably a growth factor type protein. The invention also relates to crosslinked polyelectrolytes multilayer films obtained by this process, and a coated surface obtained therefrom