The life span and serum lipids of Sprague-Dawley rats was examined following partial hepatectomy. Adult Sprague-Dawley rats were divided into two groups. One group received a 30% partial hepatectomy (30H) and the other underwent sham-surgery(control). Moreover, group 30H rats were divided into two subgroups based on length of survival ; a short life span group (30HS, n=4), and a long life span group (30HL, n=4). Blood was collected at 24 weeks after partial hepatectomy, and effects on serum biochemical parameters and longevity were evaluated. The 30HS group gained weight more rapidly than the 30HL group. Serum lipids in the 30HS group were higher than those in the 30HL group. These results indicate that survival rate may be related to early changes in lipid metabolism after partial hepatectomy
